Fig. 2. Roxyl-ZR suppresses the proliferation of OSCC. (A) Metabolism of UM1 and TSCCA cells was inhibited using Roxyl-ZR in a dose- and time-dependent manner compared with the other groups, as determined by CCK-8 assay. (B) Roxyl-ZR effectively inhibited the proliferation of UM1 and TSCCA cells in 5 days (compared with the groups, as determined by colony formation assay). (C) Roxyl-ZR dramatically suppressed the proliferation of UM1 and TSCCA cells by decreasing the ratio of BrdU⁺ cells, as determined by APC-BrdU staining.